Polymorphism of Sulfathiazole
نویسنده
چکیده
This examination of the phenomena of polymorphism, the formation of different crystalline structures within the same chemical compound, is divided into two sections. The theory of polymorphism includes definitions and characteristics of polymorphs, mechanisms and conditions under which polymorphs form, and techniques for identifying and analyzing these polymorphs. The evaluation of a sulfur-containing pharmaceutical compound, sulfathiazole, by differential scanning calorimetry (DSC) for polymorph characteristics will be the focal point of this project. The effects of solvent and temperature, as well as the solubility of each compound, will be observed. Graphical data will be included to illustrate the transformations and melting points of each polymorph. ACKNOWLEDGEMENTS Without the opportunity, support, and direction provided by Dr. Marcy Hamby Towns, this culminating Honors thesis would not be possible. I would also like to thank the distinguished chair and professor, Dr. Robert Morris, of the Department of Chemistry for his unwavering belief in me as both a scientist and an individual. I am indebted to Dr. Michael Hursthouse, Professor of Chemistry, and his colleague Ms. Ann L. Bingham, at the University of Southampton, the United Kingdom. I am grateful for their willingness to share with me their exhaustive research concerning polymorphism of sulfa compounds from "across the pond."
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تاریخ انتشار 2003